Drugs to Avoid for Brugada Syndrome

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UPDATE as of 1/24/2015:

• Allapinine and Ethacizine have been added to the "To Avoid" list. These drugs may be used to treat heart rhythm disorders like atrial fibrillation and extrasystoles but may result in adverse events in Brugada patients.
• Bupropion has been added to the "Preferably Avoid" list. Bupropion may be used as an anti-depressant. Data has emerged that this drug may be associated wtih uncovering Type-1 Brudgada ECG and as such may precipitate arrhythmias.

BrugadaDrugs.org has been initiated by the University of Amsterdam Academic Medical Center, department of Cardiology, as an aid to physicians who treat patients with Brugada syndrome and as an aid to patients with Brugada syndrome.

Many drugs have been associated with the type-1 ECG and/or with arrhythmias in Brugada syndrome patients. We have divided these drugs into four lists (together with the available evidence in the literature and a recommendation from the BrugadaDrugs.org Advisory Board) :

• Red list: drugs that should be avoided by Brugada syndrome patients
• Orange list: drugs that preferably should be avoided by Brugada syndrome patients
• Green list: drugs that may have an antiarrhythmic effect in Brugada syndrome patients
• Blue list: drugs used to diagnose the Brugada syndrome ECG
• Purple list: contains a complete list of the above mentioned drugs to (preferably) avoid for patients to give to all their health care providers